Synthetic Psilocybin: A Quick Guide
Welcome back to Weekly Mind Watering!
In this edition, we’re exploring the differences between:
👉 The natural psilocybin we all know and love.
👉The synthetic psilocybin used in therapy and academic research around the globe.
We’re taking a look at 3 key differences between these two forms of psilocybin –
Exploring their roots, uses, and roles in psychedelic study and culture.
Let’s dive in!
Nature's Own vs. Lab-Created
Psilocybin is naturally present in over 200 species of “magic” mushrooms.
These natural wonders have been cherished for centuries their ability to unlock deeply immersive psychedelic experiences.
On the other hand, synthetic psilocybin is the brainchild of modern science.
It’s predominantly utilized in controlled clinical environments where exact dosing is paramount to research integrity and therapeutic outcomes.
This lab-made psilocybin mirrors its natural counterpart, but isn’t an exact replica.
Production & Sourcing
Natural psilocybin is sourced directly from ”magic” mushrooms, which can be carefully cultivated in controlled environments or harvested from the wild.
While this connection to nature adds a layer of authenticity and historical use, it also introduces a degree of unpredictability.
Psilocybin concentration can vary wildly depending on environmental and genetic factors.
While this can potentially lead to unpredictable experiences, many microdosers solve this by simply blending their mushrooms to evenly distribute the psilocybin.
Synthetic
In contrast, synthetic psilocybin is produced through precise chemical processes in laboratories.
This method focuses on creating a pure, isolated form of psilocybin, free from the variability seen in natural sources.
Each batch of synthetic psilocybin is carefully measured and controlled to ensure that every milligram is exactly the same as the next.
The Chemical Question
So, are natural and synthetic psilocybin different on a chemical level?
Yes and no. I’ll explain –
Regardless of how the psilocybin is created in labs or by “magic,” the psilocybin molecule remains the same.
It’s the presence of additional psychoactive molecules that create a different effect.
Natural psilocybin can be accompanied by many other psychoactive compounds. The most common are:
- Psilocin
- Baeocystin
- And norbaeocystin
As we mentioned above, synthetic psilocybin is an extremely pure, highly isolated form of psilocybin.
While the impact of psilocin, baeocystin, and norbaeocystin is still unclear, researchers agree their presence impacts the mushroom experience.
Final Thoughts
👉 Natural psilocybin connects us to a long history of traditional use and offers a complex array of psychoactive compounds.
👉 Synthetic psilocybin provides the consistency and purity necessary for rigorous scientific research and precise therapeutic applications.
As psychedelic research, normalization, and use become more popular by the day, both types of psilocybin will undoubtedly play a role in our collective growth, fulfillment, and realization.
Ready to Learn More?
Watch:
Total Synthesis’:
"Psilocybin Synthesis in 4 Steps "
